The Desperate Housewives actress said Depp would be her first choice if she had to share an onscreen kiss with a fellow celebrity.
However, she admitted that she would be rendered speechless by his looks if the opportunity ever presented itself.
She told the Sunday Mirror: "I'd probably be too nervous to talk to him because he's so beautiful."
She added that she was looking forward to Valentine's Day on Thursday, saying: "I love love. I’m in love, we’re all in love. I’m just in love with the whole thing. I’m a hopeless romantic. That’s really me."
Longoria's husband Tony Parker recently he was shocked by reports that he cheated on her last year.
